I attended a high school festival recently where one of the class themes was a celebration of individuality.
And among the various exhibits the students had made was a poster with those famous words of Goethe:
Whatever you can do, or dream you can do, begin it. Boldness has genius, power and magic in it.
Having watched these students take that theme from concept to execution, despite being very busy with their studies, I think the seeds of success in any major goal (such as career change or finding meaningful work) come down to the two B words:
Boldness and Begin.